micro2MACRO

A bioprinting platform for the rapid, reliable, controlled and quantifiable patterning of cellular aggregates and microtissues into macroscale regenerative grafts with programmable architectures 

About m2M

The main goal of micro2MACRO (m2M) 
is to develop a new bioprinting platform capable of spatially patterning cellular aggregates or microtissues into scaled-up, personalised durable load-bearing grafts and guiding their (re)modelling into fully functional tissues in vivo within damaged or diseased environments.

m2M will last for 48 months and brings together leading academic institutions, research centers, and companies to create a system for producing personalised, scalable grafts that can support the repair of damaged tissues.

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Our objectives

1.

To develop an automated platform for the high-throughput generation of phenotypically distinct microtissues (μTs) in a robust and reproduceable manner.  

2.

To design and build sensor-equipped micro-extrusion and inkjet printheads capable of real-time monitoring of bioink properties, including cellularity (i.e., cell or μT number) and shape fidelity.  

3.

To produce bioinks for the bioprinting of cellular aggregates or μTs, incorporating glucose, oxygen & growth factor releasing biomaterials to maintain cellular viability (self-sustaining bioprinted tissues) and direct differentiation.

4.

To develop a GMP conform convergent bioprinting platform to guide the fusion, growth and (re)modelling of multiple cellular aggregates or μTs, resulting in the development of large scale, anisotropic tissues with user-defined matrix architectures.

5.

To bioprint osteochondral and maxillofacial grafts and assess their regenerative potential using in vitro, ex vivo and in vivo models. 

6.

To prepare for rapid market introduction and clinical uptake of the bioprinted implants by developing a detailed exploitation and regulatory strategy in collaboration with market parties. 

7.

To implement the convergent biomanufacturing process in a GMP-simulation environment.

Our team

Meet our project partners

Insights

Read our recent published news.

We’re pleased to present the latest collaboration between our partners from at

The University of Helsinki, a key collaborator in our ongoing efforts, recently

Regenerative Medicine Utrecht, our partners in the m2M framework, have recently published