Metatissue - BioSolutions
Metatissue is a spin-off from Aveiro University focused on developing human protein-derived biomaterials for advanced cell culture, tissue engineering, regeneration, and disease modeling. Metatissue collaborates with clinical partners, regulators, investors, and technology transfer offices to scale up and introduce innovative bioinks to the market. Our biomaterials create realistic microenvironments that enhance cell-to-cell and cell-to-matrix interactions, improving in vitro study accuracy. By developing hydrogels, sponges, and bioinks from chemically modified human proteins, we drive advancements in 3D cell culture and personalized medicine. Our technology also aims to reduce or replace animal testing, making drug development more efficient, cost-effective, and ethically responsible.
Work in m2M
Metatissue plays a key role in focusing on the design, synthesis, and scaling up of PLMA-based bioinks. As the primary supplier and industrial partner, Metatissue defines material requirements, provides components and reference samples, and ensures the bioinks support bioprinting of cellular aggregates and microtissues. Collaborating closely with partners, Metatissue contributes to the development of self-feeding bioinks that maintain cell function and viability while aligning with GMP-compliant biomanufacturing and regulatory standards.
Researchers involved
Past Publications
- Caiado Decarli et al. Embedding Bioprinting of Low Viscous, Photopolymerizable Blood-Based Bioinks in a Crystal Self-Healing Transparent Supporting Bath. Small Methods 9, e2400857 (2025).
- Monteiro et al. Tumor-On-A-Chip Model Incorporating Human-Based Hydrogels for Easy Assessment of Metastatic Tumor Inter-Heterogeneity. Adv. Funct. Mater. 34, 2315940 (2024).
- Santos et al. Human Protein-Based Porous Scaffolds as Platforms for Xeno-Free 3D Cell Culture. Adv. Healthc. Mater. 11, e2102383 (2022).
- Monteiro et al. Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human-Based Hydrogel Platform. Macromol. Biosci. 24, e2400227 (2024).
- Sobreiro-Almeida et al. Leveraging Blood Components for 3D Printing Applications Through Programmable Ink Engineering Approaches. Adv. Sci. 11, 2406569 (2024).
